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Additional information on lab reports.

KRAS Mutation Analysis by PCR

KRAS Mutation Analysis by PCR Clinical Significance The KRAS proto-oncogene encodes a GTPase that functions in signal transduction and is a member of the RAS superfamily which also includes NRAS and HRAS. RAS proteins mediate the transmission of growth signals from the cell surface to the nucleus via the PI3K/AKT/MTOR and RAS/RAF/MEK/ERK pathways, which regulate …

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EGFR Mutation Analysis by PCR

EGFR Mutation Analysis by PCR Clinical Significance Recurrent somatic mutations in the tyrosine kinase domain ﴾TKD﴿ of EGFR are observed in approximately 10‐20% of lung adenocarcinoma, and at higher frequencies in never‐smoker, female, andAsian populations[PMID: 20388509; PMID: 25079552; PMID: 24071849; PMID: 22588877]. The most common mutations occur near the ATP‐binding pocket of the TKD and …

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